Monitor Carefully (1)pentobarbital will enhance the stage or effect of clopidogrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the extent or influence of oliceridine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. If coadministration having a CYP3A4 inducer is critical, consid